Principal Statistical Programmer

Summary of Key Responsibilities
* Write programs that produce or validate tables, listings, figures and analysis datasets, insupport of clinical studies or complex integrated analyses for submission;
* Develop and follow good programming practices, including adequately documentingSAS and R code;
* Perform, plan and coordinate project work to ensure timely, quality delivery acrossmultiple projects;
* Use, modify, and maintain existing SAS and R code;
* Write specifications to describe programming needs;
* Create and validate global macros or systems that streamline repetitive operations toincrease programming efficiency;
* Keep abreast of current and new statistical programming techniques and otherapplicable technical advancements while assisting in their implementation;
* Provide input into, or lead general standardization efforts (e.g., CRFs, query checks,standard statistical programs, data presentations);
* Assist or lead efforts to develop programming processes consistent with industry bestpractices;
* Review DMP, eCRF specs, and other clinical data management documents;
* Review statistical analysis plans and other related documents;
* Partner with or oversee CROs or Programming vendors to perform any of the abovetasks;
* Other duties as assigned.

Qualifications
* At least 8 years' industry (Pharmaceutical, Biotech, CRO) SAS programming experienceor equivalent;
* Knowledge of clinical trials and experience in using SAS to report the results of clinicaltrials and/or integrated analysis for submission;
* Experience in constructing technical programming specifications and producingcomplex, validated programs;
* Strong experience in working with CDISC standards, including SDTM, and ADaM, andDefine xml;
* Preferred experience in R programming;
* Excellent knowledge of applied statistical methodologies;
* Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT;
* Good communication and organizational skills required;
* Bachelor's Degree required, Master's Degree Preferred.
* Clear alignment with Alnylam Core Values:

• Commitment to People
• Innovation and Discovery
• Sense of Urgency
• Open Culture
• Passion for Excellence

U.S. Pay Range

$149,300.00 - $201,900.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.