Principal Associate Scientist, Research (RNAi Biology & siRNA Delivery)

The Research Department at Alnylam is seeking a passionate and enthusiastic Principal Associate Scientist to join our interdisciplinary team focused on advancing extrahepatic siRNA delivery and our mechanistic understanding of RNAi biology across tissues, specifically skeletal muscle, heart, and kidney. The role requires a strong background in biological sciences and technical skillsets in in vitro cell culture as well as molecular and biochemical assays. Prior experience or a willingness to learn in vivo rodent work is strongly preferred. We seek someone who will flourish in a goal- and timeline-oriented collaborative environment and be able to rapidly learn new topics and experimental techniques.

This position islab-based onsiteand will be primarily located in Cambridge, MA.

Key Responsibilities

• The candidate will engage in a variety of mechanistic in vitro and in vivo siRNA research efforts to evaluate RNAi compounds, utilizing biochemical, molecular, and cell-based assays.
• Design, execution, interpretation, and troubleshooting of experiments on an individual basis as well as part of a collaborative team.
• Presentation of results in both written and oral format to key stakeholders within the Research organization.

Qualifications

• BS/MS in Biology, Biochemistry, or related field with 6+ (BS) or 4+ (MS) years of work experience, preferably in industry setting
• Prior experience and/or working knowledge of nucleic acid-based therapies (siRNA, ASO, CRISPR) is highly desired.
• Proficiency in mammalian immortalized and primary cell culture (maintenance, transfection/stable selection).
• Proficiency in DNA/RNA squence evaluation and plasmid design.
• Proficiency in routine molecular biology assays to support evaluation of siRNA acitvitiy (qPCR, Western Blotting, ELISA, Ago-immunoprecipitation, etc.).
• Prior experience with advanced cell models, including generation and/or CRISPR editing of iPSC-derived cell lines would be highly valuable.
• Molecular biology assays to support evaluation of siRNA activity (qPCR, Western blotting, ELISA, Ago-immunoprecipitation, etc.).
• Experience with (or willingness to learn) in vivo rodent handling and experimentation is a plus.
• Excellent lab technique and ability to work independently.
• Strong interpersonal skills and excellent communication skills (written and oral) are required.

U.S. Pay Range

$97,300.00 - $137,100.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.