Principal Scientist, Translational Imaging

The Research Department at Alnylam is seeking a passionate and creative computational imaging scientist to join the Translational Genetics and Medicine Group and play a critical role in utilizing human data and clinical insights to enhance the discovery, validation, and prioritization of new therapeutic targets and indications. Our team aims to enhance the organization's ability to deliver new therapeutics to patients by 1) deriving known and novel disease-relevant phenotypes from different imaging modalities, and 2) utilizing these image-derived phenotypes to power genetic discovery, identify and validate biomarkers, and help plan for clinical trials. The successful candidate will be part of a team that works collaboratively across preclinical and clinical sciences with a focus on providing imaging analyses and expert advice across organ systems.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Strong desire to perform individual contributor work in a collaborative context and communicate findings to biologists and clinicians.
• Read the literature, derive own insights, and identify novel data and analyses methods to answer questions related to established and novel image-derived phenotype generation.
• Work with clinicians and external experts to understand and identify the best imaging protocols and ground-truth image annotations across disease areas.
• Apply computational imaging and deep learning techniques (including fine-tuning existing models) to both small-scale and biobank-scale (100k+ images) volumetric image datasets.
• Gain increasing ability to guide preclinical and clinical imaging strategy with high quality literature reviews combined with in-house data analyses, e.g. to identify emerging quantitative imaging modalities with applications to our clinical programs.
• Will be expected to manage workload including balancing large-scale exploratory projects with targeted time-sensitive requests.
• Strong written and oral presentation skills, ability to draft high quality scientific manuscripts and presentations for internal/external use.

Qualifications

• PhD in computational image analysis, biomedical engineering, or a specialized field such as neuroscience with a strong emphasis on image analysis with 5+ years of postgraduate work (academia and/or industry).
• Demonstrated ability to work with at least one volumetric imaging type in depth that generalizes to competency with analyses of optical coherence tomography, brain MRI, whole body MRI, and other image types. Experience with additional emerging technologies and quantitative modalities (e.g. spectroscopy) is a plus.
• Proven track record of working with imaging datasets, sharing code, scaling up analyses, and showcasing results in either manuscripts, conferences, or similar.
• Proficiency in python and/or R, experience with computational and cloud infrastructures (AWS, UKB RAP) and databases.
• Experience with the UKB Imaging, ADNI, AREDS and/or similar datasets is a plus.
• Experience interacting with clinicians or expert image readers is a plus.

U.S. Pay Range

$148,200.00 - $208,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.