Scientist, Next Wave, Target Discovery & Validation

The Research Department at Alnylam is seeking a highly motivated and creative scientist to join our Next Wave Target Discovery and Validation team. Our mission is to discover novel therapeutic targets for RNAi-based treatments in disease areas with high unmet need. This position offers a unique opportunity to work with interdisciplinary teams and collaborate closely with colleagues in human genetics, translational science, RNAi platform research, and clinical development to fuel the future RNAi pipeline.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Identify and prioritize novel RNAi targets via human genetics, literature review, systems biology and experimental approaches
• Design and execute in vitro and in vivo studies to validate candidate targets and elucidate the underlying mechanisms of action
• Analyze, interpret and present scientific data in internal meetings and contribute to strategic planning discussions
• Collaborate with external partners, including CROs and academic institutions; lead project planning and data interpretation
• Collaborate and communicate results with key stakeholders throughout the organization
• Mentor associate scientists
• Provide mentorship to junior scientists within the team

Qualifications

• PhD in biology, biomedical sciences, or a related field; postdoctoral experience preferred but not required
• Strong scientific curiosity with the flexibility to quickly learn and apply knowledge to new areas
• Proven expertise in developing and characterizing in vitro, ex vivo, and in vivo models, with a strong understanding of disease biology, pathogenesis and mechanisms of action
• Hands-on experience with in vivo animal models is required
• Familiarity with the application of genetics and genomics approaches (e.g., GWAS) to inform biological understanding is a strong plus
• Thrive in a fast-paced team environment and possess excellent communication skills (both written and oral).
• Prior industry experience is a plus but not required

U.S. Pay Range

$111,400.00 - $157,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.