Senior Director, Supply Chain Digital Strategy

The Senior Director, Supply Chain Digital Strategy will be a key business leader responsible for shaping and delivering the digital transformation vision for Alnylam's supply chain. This role will own the digital supply chain product vision and roadmap, ensuring that investments in data, systems, and processes deliver measurable business value across Clinical and Commercial Supply, Global Planning, and Logistics.

Anchored in supply chain but collaborating across Technical Operations & Quality (TOQ) - including CMC, Manufacturing, Quality, and Facilities - this leader will align digital priorities across functions, enable seamless data integration, and standardize core business processes. Acting as the business counterpart to IT, they will define enterprise process and data standards, prioritize initiatives, and drive adoption strategies that ensure technology solutions are scalable, connected, and future-ready.

This is a hybrid position based primarily at Alnylam's Cambridge, MA office. The individual in this role will be expected to work on-site at least two days per week. At this time, we are not considering remote candidates.

Key Responsibilities

• Serve as the business owner for supply chain digital products, ensuring a clear, cohesive product vision aligned with enterprise strategy.
• Develop and maintain a multi-year digital roadmap that balances innovation with operational readiness.
• Prioritize digital initiatives based on business value, feasibility, and strategic fit.

• Define and implement robust business-side data governance structures across supply chain domains.
• Establish clear data ownership and stewardship roles in partnership with IT, ensuring process accountability and alignment with enterprise governance standards.
• Ensure data integrity, harmonization, and lifecycle management across planning, inventory, distribution, and manufacturing master data.

• Partner with IT to drive seamless interoperability across core systems, including ERP, CTMS, MES, LIMS, and planning platforms.

• Ensure end-to-end integration between Clinical and Commercial Supply systems, enabling visibility and data flow across the product lifecycle.
• Support integration of Clinical Supply systems including IRT, CTMS, and clinical forecasting tools with enterprise systems to enable protocol demand visibility, country-specific supply planning, and inventory tracking.

• Develop and execute change management and adoption strategies to ensure new capabilities are fully utilized.
• Measure and communicate realized business value from digital investments.

• Lead the design of scalable digital engagement models with CMOs, suppliers, and 3PLs to enable visibility, traceability, and real-time data exchange.
• Define business process expectations and data standards for external integration platforms.

• Establish and govern enterprise supply chain KPIs and digital performance metrics.
• Enable self-service data access and operational dashboards for decision-making.

• Build foundational data/process infrastructure for AI, predictive analytics, and machine learning.
• Partner with analytics teams to pilot and scale advanced capabilities.

• Champion a culture of digital fluency and data-driven decision-making.
• Lead cross-functional training, engagement, and continuous improvement initiatives.

Qualifications

• Bachelor's or Master's degree in Supply Chain, Information Systems, Engineering, or a related field.

• 15+ years in supply chain, operations, or digital transformation in life sciences.
• Proven track record leading enterprise digital strategy and product vision execution.
• Deep expertise in systems integration, data governance, and business process architecture.
• Experience implementing major platforms across ERP, APS, MES, LIMS, WMS domains.
• Strong cross-functional leadership and change management skills.

• Strategic thinker with a systems mindset and ability to connect data, process, and platform design.
• Collaborative leader who can influence across business, IT, and external partners.
• Strong understanding of supply chain operating models, KPIs, and external collaboration frameworks.
• Experience with data governance frameworks and enterprise-level change management.

U.S. Pay Range

$226,200.00 - $306,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science,Alnylamhas delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values:fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.