Senior Scientist, Discovery & Translational Research

We are looking for a self-starter with expertise in skeletal muscle or cardiovascular research to fill a Senior Scientist role in the Discovery and Translational Research team at Alnylam. This individual will join a multidisciplinary group that identifies, validates, and develops drug candidates. The breadth of responsibilities spans from discovery through clinical development, including experimental work in preclinical disease models, leading the Development Candidate discovery efforts, and working with multidisciplinary teams to support preclinical and clinical development.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Work closely with Alnylam's Target Discovery, Human Genetics, Multi-Omics, Platform, and Clinical Research teams
• Acquire deep knowledge of target biology to serve as a Research Lead for specific target(s)
• Design and execute proof-of-concept experiments in animal and in vitro disease models to support targets at various stages of development
• Design studies, coordinate activities, and lead from the bench
• Oversee lead discovery activities for the selection of drug candidates for further development
• Develop assays to monitor target engagement/pharmacodynamic responses
• Work with multifunctional teams to shepherd a drug candidate through the lead selection and development process to the clinic
• Initiate and manage relationships with contract research organizations (CROs) and/or academic collaborators, including the development of research plans and data analysis
• Mentor junior scientists
• Collaborate and communicate results with key stakeholders throughout the organization

Qualifications

• PhD + postdoc in Cell Biology, Molecular Biology, Biochemistry, Immunology, Genetics, or a related field
• At least 3+ years of industry experience, or equivalent, are preferred.
• Expertise in skeletal muscle (e.g., rare muscle diseases) or cardiovascular basic research or translational medicine (e.g., heart physiology, heart failure, arrhythmias)
• Existing focus on disease biology and prior experience with mammalian disease models are preferred
• Strong publication record
• Solid organizational skills and the ability to multitask are a must
• The successful candidate will have strong interpersonal and communication skills, a track record of working on teams, an interest in learning new biology, and a passion for lab work

U.S. Pay Range

$127,300.00 - $179,500.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.