Manager, Molecular Pathology Lab

The Pathology team is seeking a Molecular Pathology Lab Manager. Experience performing and evaluating immunohistochemistry and/or in situ hybridization is essential. Interpretation of labeled specimens requires an understanding of anatomy and histology and an ability to identify specific cell populations in tissue sections. Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.

Laboratory Management:

• Oversee laboratory workflows related to advanced molecular techniques including immunohistochemistry and in situ hybridization
• Manage a group of 4 or more people with growing molecular and image analysis expertise
• Ensures compliance and alignment with all EH and S initiatives within the Molecular Pathology Laboratory
• Experience instituting and maintaining Laboratory Information Systems
• Operates within a quality management system and collaborates with quality assurance and regulatory team to improve laboratory processes, optimize methods, and develop quality analytics
• Responsible for authoring, reviewing, and revision of pathology lab related SOPs and Policies
• Experience with online ordering of lab materials, reagents, as well as maintaining inventory of lab supplies
• Ensures ELN (electronic lab notebooks) are kept up to date in a complete and consistent manner, following all legal requirements as well as keeping clear and complete record
• Maintains a schedule of molecular pathology laboratory-related activities for both in-house and out-sourced research studies
• Supports validation of new assays and instruments for molecular histology

Scientific & Technical Leadership:

• Maintains knowledge of scientific technological developments by reading the current literature and attending professional conferences to develop innovative concepts, which may lead to new assays, equipment requests, and/or procedures.
• Participates in planning and execution of eDEV and research projects. This includes helping review protocols and aligning laboratory resources.
• In collaboration with pathologists, may present experimental results to senior scientific staff
• May prepare and/or contribute to articles for publication.
• Develop relationships with teams within eDEV and broader ReDev to enhance collaboration and streamline processes.

Mentoring:

• Possesses specific problem solving and people management skills
• Actively seeks and delivers coaching and feedback to employees
• Builds collaborative relationships among team members and works cooperatively with others. Adapts well to change, and functions well with ambiguity
• Demonstrates the ability to manage conflict
• Direct day to day operations of the Molecular Histology Laboratory
• Act as Team Leader for Molecular Histology team

• Bachelor's degree or higher in life sciences field/+10 years industry experience
• ASCP Histotechnician certification(s)
• Routinely demonstrates initiative that has direct impact on the pathology labs operation, improvement and refinement.
• Ability to communicate and present complex scientific information to scientific and non- scientific audiences.
• Ability to make decisions autonomously and requires minimal guidance to perform job duties.
• Communicates openly and directly with laboratory group, departmental and cross-functional scientific groups, and management.
• Proven leadership abilities and project management, evidenced by history of successful project delivery and successful timelines completed
• Strong analytical, problem solving, and decision-making skills.
• Minimum Qualifications:
  o BS in life sciences with 5-10 years of relevant laboratory experience or Masters degree with 3+ years of relevant laboratory experience.Essential skills:
• Demonstrated ability performing IHC and/or ISH (including multiomic spatial profiling).
• Demonstrated ability to manage lab staff and laboratory operations
• Experience in biotechnology or CRO-based pathology laboratory setting
• Experience with Ventana, Leica or other automated immunostainers
• Experience with ACD RNAscope
• Experience with data entry, ELN, LIMS systems
• Desirable skills:
• Experience collecting and reporting laboratory metrics
• Solid report writing skills
• Experience performing AI-assisted image analysis and quantitative morphometrics (ie HALO etc)