Animal Study Associate/Lab Manager - 139272

Under general supervision, the incumbent will function as study director on animal studies (minipigs) and be responsible for preparation of study protocols, standard operating procedure, study scheduling and conduct, data collection, data analysis, and preparation of final reports describing study findings. Responsible for anesthesia, surgery, and physiological monitoring of rodents (rats, mice) investigations. Responsible for all aspects of rodent studies relating to neuro-anesthesia, including the set up, calibration and trouble shooting of monitoring/testing equipment, and colony management.

Perform calculation and administration of anesthetic drug dosages including investigational test articles, anesthetics, and pre- and post-surgery medications. Responsible for post-operative and critical care of experimental animals including managing respiratory and cardiac function, harvesting of organs for pathological exam, and compliance with all laboratory animal control and care regulations. Oversee the use of controlled substances (Class 1-V) including their inventory, purchase, maintenance of usage logs, disposal, and personnel training.

Work alongside the PI with small animal surgeries related to spinal transplantation of neuronal precursors. Perform whole body perfusion fixation and necropsy in mice and rats. Dissection of spinal cord and brain tissues. Prepare frozen and vibratome-cut spinal cord and brain sections from rats and mice and perform immunofluorescence staining. Performs additional, similar duties added as needed.

• Theoretical Knowledge of Animal Science, Animal Physiology and/or Biology.

• Theoretical knowledge of pharmacology and pharmacokinetics related to rodent experimentation.

• Theoretical knowledge of histology.

• Proven experience working with animal anesthesia and associated equipment; anesthetic vaporizers, flowmeters, gases and circuit systems. Calibration and experience with micro-blood gas/pH analyzers, pressure records, glucose/lactate analyzers, and other laboratory equipment used to analyze blood samples.

• Experience with rodent surgical procedures, sterile, and suturing techniques, and surgical instruments. Experience in rodent tissue harvesting techniques including spinal cord, brain, liver and kidney tissue.

• Experience interpreting physiological tests for large laboratory animals including CSF (glucose, protein, white blood count, specific gravity, hematocrit, blood, chemistry panel).

• Experience with injections including subcutaneous, intramuscular, intraperitoneal and intradermal injections.

• Proven knowledge, experience, and demonstrated ability in ensuring that proper safety requirements are enforced, particularly relating to the use and disposal of biohazardous agents and toxic chemicals

• Experience with sample collection including, intrathecal, intravenous, urine collection. Manual dexterity is required for conduct of all assay laboratory protocols.

• A good communicator, able to train and supervise personnel. Ability to conduct informal presentations; ability to work with a diverse group of investigators.

• Intermediate-to-advanced skill using spreadsheets, graphics and statistical software; experience using Excel, Prism, Stats/Graphics, Photoshop, and Adobe Illustrator. Proven skills in data collection, handling and statistical analysis.

• Successful completion of UCSD Environmental Health and safety controlled substances training, working knowledge of regulations and compliance of controlled substances guidelines. Successful completion of UCSD IATA hazardous material and diagnostic specimen shipping training, working knowledge of shipping regulations.

• Must be willing to work with biohazardous (human, carcinogens) radioactive, corrosive and flammable materials.

• Must be willing to work some weekends and occasional overtime.

• Job offer is contingent upon satisfactory clearance based on Background Check results.

If employed by the University of California, you will be required to comply with our Policy on Vaccination Programs, which may be amended or revised from time to time. Federal, state, or local public health directives may impose additional requirements.

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

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The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

For the University of California's Anti-Discrimination Policy, please visit: https://policy.ucop.edu/doc/1001004/Anti-Discrimination

UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening.

Misconduct Disclosure Requirement: As a condition of employment, the final candidate who accepts an offer of employment will be required to disclose if they have been subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct; or have filed an appeal of a finding of substantiated misconduct with a previous employer.

a. "Misconduct" means any violation of the policies governing employee conduct at the applicant's previous place of employment, including, but not limited to, violations of policies prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer. For reference, below are UC's policies addressing some forms of misconduct:

• UC Sexual Violence and Sexual Harassment Policy
• UC Anti-Discrimination Policy
• Abusive Conduct in the Workplace