Research Postdoctoral Fellow - Neurogenesis Research - Lefebvre Lab

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A Brief Overview
Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

A postdoctoral fellow position is available in the Lefebvre laboratory at the Children's Hospital of Philadelphia (CHOP) Abramson Research Institute.

The fellow will contribute to a project aimed at elucidating mechanisms whereby SOX5 variants cause Lamb-Shaffer syndrome, a neurodevelopmental disorder characterized by global developmental delay, intellectual disability and autism spectrum disorder features and at testing a gene therapy candidate approach for this disorder in preclinical models. The fellow will use cutting-edge approaches in mouse genetic models, human iPSC-derived brain organoid models, high-throughput 'omics' approaches and gene therapy strategies. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge and to increase mechanistic understanding of neurodevelopmental diseases and our ability to treat them. It is also anticipated to help the fellow launch a promising career as an independent research investigator.

Strong candidates for this position will be eager to contribute to pioneering translational research. They will have obtained an M.D. or Ph.D. degree in the last three years, will have a solid scientific research track record, including first-author publications relevant to the project, and will have outstanding communication, organizational and interpersonal skills.

Candidates should send their curriculum vitae, a description of research interests and career goals, and contact information for three or more Faculty-level references.

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate - Required

Skills and Abilities

• Ability to wear a respirator device

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SALARY RANGE:

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

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