About Client:
The Client is known for its groundbreaking work in genetic engineering and biopharmaceuticals. It was the first company to successfully produce a recombinant version of human insulin, which revolutionized the treatment of diabetes. Since then, it has developed numerous other important biotech drugs, particularly in the fields of oncology (cancer treatment) and immunology.
Rate Range: $53.60-$91.26/Hr
Job Description:
- Pathology Biology & Integrated Analytics group (Pleasanton, CA) at Roche Diagnostics is seeking a highly
- motivated Scientist for molecular cloning, cell culture, FPLC purification and antibody engineering and characterization.
- The qualified candidate will join a team of scientists focused on monoclonal antibody development for IVD and CDx assay.
- This position will be actively participating in antibody development, engineering, production and characterization.
- Job function requires the ability to evaluate, summarize and report study results, make independent decision and collaborate with teams at multiple sites.
Responsibilities:
- Plans and/or manages smaller, less complex local projects (e.g. with moderate project management complexity, problem definition, and/or short to medium term implications).
- Participates in project teams across the R&D department and functional groups
- Can represent the Team Lead in project teams in his/her absence on instruction
- Ensures that quality standards are met and plans and coordinates the performance of tasks largely independently.
- Is aware of new developments in the field and refers to the possible use of these in diagnostics.
- Contributes to collaboration and close networking within the departments as part of R&D projects.
- Analyzes and interprets the R&D results largely independently and presents them to the relevant committees within their own function.
- Uses specified strategies to resolve problems and acts within defined guidelines.
Soft skills:
- Strong work ethic and collaborative attitude.
- Proven capacity to work effectively and positively in a small, tight-knit team, supporting colleagues and contributing to a shared goal.
- Strong analytical skills to interpret complex experimental results and troubleshoot unexpected technical challenges.
- Proactive approach to identifying potential project roadblocks and proposing solutions.
- Excellent communication and leadership skills with a deep commitment to working as part of teams and recognizing the strengths of everyone on the team.
- Ability to clearly and concisely present complex data (written and verbal) to both scientific and non-scientific team members.
- Ability to efficiently manage multiple tasks and pivot priorities as research needs evolve.
- Demonstrates self-motivation and the initiative to drive the project forward independently.
- Excellent organizational skills to manage laboratory resources, schedules, and deadlines effectively to ensure key milestones are met.
Hard skills (Core Requirements):
- Demonstrated experience with the end-to-end antibody development process, from molecular cloning through expression, purification, and biochemical/functional characterization.
- Advanced proficiency in standard molecular cloning techniques (e.g., PCR, restriction/ligation, Gibson assembly) for subcloning antibody sequences into mammalian expression vectors.
- Strong hands-on experience analyzing and manipulating antibody sequences, with a deep understanding of antibody architecture (VH/VL, CDRs, frameworks) and routine use of sequence analysis tools to support antibody engineering.
- Hands-on experience expressing antibodies in mammalian systems (e.g., HEK293, CHO).
- Demonstrated experience in antibody purification and characterization, including protein A/Gbased purification (e.g., FPLC) and downstream analytical methods such as ELISA, SDS-PAGE, WB, HPLC and IHC.
Is a Plus:
- Experience with laboratory automation and workflow optimization (e.g., automating cloning, expression, purification, or analytical assays).
- Ability to interpret structural data (PDB files) and relate it directly to experimental outcomes (e.g., binding, stability).
- Knowledge of biophysical characterization techniques (eg. DSC, DLS) to assess protein structural integrity and stability.
- Experience with computational protein engineering and antibody epitope modeling.
- Experience with advanced protein modifications analysis and their impact on function.
- Familiarity with formulation and stability studies for final antibody products.
Hard skills:
- Experience and in-depth knowledge in monoclonal antibody development and antibody engineering.
- Proficiency in standard cloning techniques (e.g., PCR, restriction/ligation, Gibson assembly) for subcloning antibody sequences into mammalian expression vectors.
- Familiarity with antibody sequences and sequence analysis software.
- Significant experience with transient protein expression in mammalian cell culture systems (e.g., HEK293, CHO).
- Experience with antibody purification and characterization (eg. FPLC purification, HPLC, ELISA, SDS-PAGE, WB, IHC).
- Domain knowledge in oncology, immunology, or protein chemistry.
- MSc. but years of relevant experience is most important 5-10 years hands on exp.
Non-benefitted (other than those mandated under state or federal law).Please note that this position does not include paid time off benefits. ApTask offers subsidized insurance coverage to our employees.
About ApTask:
ApTask is a leading global provider of workforce solutions and talent acquisition services, dedicated to shaping the future of work. As an African American-owned and Veteran-certified company, ApTask offers a comprehensive suite of services, including staffing and recruitment solutions, managed services, IT consulting, and project management. With a focus on excellence, collaboration, and innovation, ApTask provides unparalleled opportunities for professional growth and development. As a member of the ApTask team, you will have the chance to connect businesses with top-tier professionals, optimize workforce performance, and drive success across diverse industries. Join us at ApTask and be part of our mission to empower organizations to thrive while fostering a diverse and inclusive work environment.
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Genesis10
53.60 91.26 Hour
paid time off
Dec 24, 2025