Research Lab Tech I

Massachusetts General Hospital
United States, Massachusetts, Boston
149 13th Street (Show on map)
Oct 01, 2025
The Vazquez-Garcia Lab at Massachusetts General Hospital, Harvard Medical School, and the Broad Institute is seeking exceptional candidates for a technologist position in our interdisciplinary team. Our lab investigates the fundamental principles of somatic evolution and immune surveillance in cancer. We use data-driven approaches to study cellular dynamics in tumors, combining single-cell genomics, cellular imaging and AI/ML approaches with large clinical datasets and experimental models. Our research draws on multi-modal data from basic science and clinical practice to understand how genomic adaptations confer selective advantages to tumor cells, act as biomarkers of therapeutic response and resistance, and sensitize tumors for targeted intervention. Our ultimate goal is to impact human health and clinical care for patients, leveraging our understanding of cancer trajectories to enable biomarkers and therapeutic strategies that anticipate and overcome tumor progression. This is a research-focused role designed for candidates aiming to gain hands-on experience in a dynamic and collaborative environment. The position is ideal for recent graduates interested in pursuing careers in biomedical research, medical school, or graduate school. The Research Technician will work closely with the PI and other lab members to execute and optimize protocols related to tissue processing, molecular biology, and high-throughput genomics. This position offers multiple opportunities for authorship on publications, skill development, and direct mentorship. More information about the lab can be found at: https://vazquezgarcialab.mgh.harvard.edu/ Education B.A./B.S. in biology, bioengineering, or a related field required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Prior laboratory experience in molecular biology or cell culture, either through academic coursework, internships, or employment 1-2 years preferred Preferred Experience: Experience with single-cell RNA-seq, ATAC-seq, WGS, or spatial transcriptomics platforms. Familiarity with handling and processing human tissues. Prior exposure to next-generation sequencing workflows. Basic data analysis or coding skills (e.g., Python, R) considered a plus. Interest in cancer biology, genomics, or immunology. Knowledge, Skills and Abilities The successful candidate will be working independently under close supervision of the principal investigator and senior lab members. The main responsibilities will include but not be limited to: Perform molecular biology techniques including PCR, qPCR, DNA/RNA extraction, gel electrophoresis, and library preparation for sequencing. Assist in the collection, processing and dissociation of patient-derived tissues and cell lines for single-cell and spatial profiling studies. Conduct tissue culture work. Prepare samples for next-generation sequencing and coordinate sample submissions. Maintain detailed and organized experimental records. Help manage laboratory inventories, including reagents and sample tracking. Contribute to protocol optimization and troubleshooting. Participate in regular lab meetings and present findings to the team. Additional responsibilities may include: Prepare and present results at local or national conferences. The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.