Systems Biology Staff Scientist

Eagle Health is seeking a Systems Biology Staff Scientist to join our team in Fort Detrick, MD.

The employee shall provide support to Systems Biology Branch tasks, including sample collection and processing, team leading and study design, and data analysis. This includes, but is not limited to, verifying assay performance, establishing sample repository, leading testing activities, and developing novel sample processing procedures. These areas will be developed within the Center for Genome Sciences and through collaborations both within and outside of the agency for host characterization using Omics (genomics, transcriptomics, proteomics, metabolomics, and epigenetics). Task support may be provided in BSL-3 and BSL-4 containment therefore enrollment in BPRP is required.

• Employee shall generate and execute protocols for the Systems Biology Branch at the Center for Genome Sciences. Perform and develop protocols for transcriptomic and proteomic (bulk, single cell and spatial), metabolomic in samples from in vitro cultures, animal model or human samples for host respond characterization to pathogen infection or treated with a specific Medical Countermeasure.
• Employee shall perform protocols for epigenetic modification in nucleic acids (RNA and DNA). Preparation of transition packages/technical reports/training documentation.
• Employee shall perform protocols using microphysiological systems (MPS), including ex-vivo tissues, organs on a chip, spheroids, organoids, and tissue 3D printing. Perform in vitro cell culture techniques to support the tasks
• Employee shall assist in the preparation of transition packages, technical reports, and training documentation. Employee shall perform technical literature searches to support and update these protocols and techniques.
• Employee shall prepare technical reports and manuscripts for publication. Employee will provide the TPOC Quarterly and Annual Reports for all associative projects.
• Employee shall establish a biosample repository for evaluation and verification. Employee shall maintain a biosample repository for testing both surveillance verification as well as the new surveillance platforms.
• Employee will provide the TPOC a Project Report outlining protocols, data and standard operating procedures for responsible projects NLT the last day of each month or as requested.
• Employee shall ensure reagents in the lab are not expired and ordered periodically to avoid shortage in reagents and stops in processes. Employee will maintain reagent, sample, and intermediary processes products inventory updated and stored in the designated areas, following biosafety guidanceand CGS protocols. Employee shall receive and appropriately storage reagents and samples delivered to the CGS. Employee shall support generation of all associative documentation for supply and equipment acquisition as necessary to complete objectives.
• The number of deliverables required will vary per year depending on the number of funded projects available, but the typical workload is management and execution of 2-4 projects per year.
• Employee shall participate in all activities pertinent to lab performance and safety, including weekly lab clean up to avoid contaminations, be primary, secondary or tertiary point of contact for equipment and/or laboratory spaces (POC will be contacted by phone during emergencies, such as alarms or loss of power, and need to respond according to emergency plan for the CGS). Employee will contact commercial company and/or agency Medical Maintenance or Clinical Engineering (CEB) when an instrument is malfunctioning or needs periodical PM, and escort engineers during the scheduled visit at the agency.
• BPRP enrollment is required and will be held and maintained IAW the provisions in this contract and all applicable regulations.